# Copyright 2002 PharmaDM N.V. # All rights reserved # # Special terms and conditions of use # # The information in this file can be freely used in the context of the # EU FP5 Quality of Life Project "BioMinT". All other use is reserved. # Use is subject to the conditions specified in the project's consortium # agreement on pre-existing know-how. In particular, any information in # this file will only be given to the project partners and to the extent # necessary for the project. This information can not be commercialised # without prior written agreement from PharmaDM. # PharmaDM makes no warranties, expressed or implied, with respect to data # contained in this file, and, furthermore, assumes no legal liability for # any party's use, or the results of such use, of any part of the data. # Semantics of this file # # Each line in this file represents one canonical form of a term representing # some (biological) influence. Fields are ";"-separated, and whitespace at # the beginning and end of each field is irrelevant. # # The first field on a line is the (canonical form of the) term itself. # # The second field is an indication of the place of the term in the # influence hierarchy, as follows : the top node of the hierarchy # has label I, and any term with label X.Y (with Y not containing # any ".") is a direct child node of the term with label X. Thus, # the node labels indicate a path from the top node to the term. # If a term occurs several times in this file with different labels, # this means there are multiple paths to this term. # (Actually, the shorter explanation is : this is the same syntax # as used in the MeSH.) # # The third field indicates the type of construct the term is typically # used in in relation to the other concepts of interest; 0-5 denote verb # constructs, e.g. 0 being the active subject-verb-object construct, # 6 and 7 are noun constructs, 8 and 9 are adjective constructs, and 10 # denotes "other" constructs. Here are typical examples of each # construct # 0 : A influences B # 1 : B is influenced by A # 2 : B requires A # 3 : A is required for B # 4 : (X) implicates A in B # 5 : A is implicated in B # 6 : ... the influence of A on B # 7 : A is a regulator of B # 8 : A is influential in B # 9 : B is susceptible to A # # The fourth field indicates if the term denotes an influence (0) or # the absence of an influence (1). # # Finally, the fifth field is a list of prepositions required for the # semantic object (B in the above examples), if different from the # default for the construct. E.g. a protein A "influences" another # protein B (B is the direct object), but it "interacts _with_" B (B # occurs in a prepositional phrase). # # For any more information or feedback, you can contact either # Kristof.VanBelleghem@pharmadm.com (especially concerning approach, # syntax and language constructs) or Andre.Vandecandelaere@pharmadm.com # (concerning biochemical content). #TERM; NODE_LABEL; TYPE; MOOD; PREPOSITION_LIST influence; I.0; 0; 0; influenced; I.0; 1; 0; influence; I.0; 6; 0; on influential; I.0; 8; 0; in act; I.0.0; 0; 0; on/upon acted; I.0.0; 1; 0; on/upon action; I.0.0; 6; 0; on/upon actor; I.0.0; 7; 0; # COMMENT:influence with an element of singularity and/or directionality affect; I.0.1; 0; 0; affected; I.0.1; 1; 0; interact; I.0.1.0; 0; 0; with interaction; I.0.1.0; 6; 0; with conjugate; I.0.1.0.0; 0; 0; to/with conjugated; I.0.1.0.0; 8; 0; to/with conjugation; I.0.1.0.0; 6; 0; to/with associate; I.0.1.0.1; 0; 0; with associated; I.0.1.0.1; 8; 0; with association; I.0.1.0.1; 6; 0; with bind; I.0.1.0.1.0; 0; 0; to bound; I.0.1.0.1.0; 8; 0; to bond; I.0.1.0.1.0; 6; 0; to ligate; I.0.1.0.1.0.0; 0; 0; ligated; I.0.1.0.1.0.0; 1; 0; ligand; I.0.1.0.1.0.0; 7; 0; of receptor; I.0.1.0.1.0.1; 7; 0; substrate; I.0.1.0.1.0.2; 7; 0; dissociate; I.0.1.0.2; 0; 0; from dissociated; I.0.1.0.2; 8; 0; from dissociation; I.0.1.0.2; 6; 0; from target; I.0.1.0.3; 0; 0; targeted; I.0.1.0.3; 1; 0; target; I.0.1.0.3; 10; 0; for attract; I.0.1.0.4; 0; 0; attracted; I.0.1.0.4; 1; 0; by/to attraction; I.0.1.0.4; 6; 0; attractor; I.0.1.0.4; 7; 0; chemoattract; I.0.1.0.4.0; 0; 0; chemoattracted; I.0.1.0.4.0; 1; 0; by/to chemoattraction; I.0.1.0.4.0; 6; 0; chemoattractant; I.0.1.0.4.0; 7; 0; repel; I.0.1.0.5; 0; 0; repelled; I.0.1.0.5; 1; 0; repulsion; I.0.1.0.5; 6; 0; repellent; I.0.1.0.5; 7; 0; of/for interfere; I.0.1.1; 0; 0; with interference; I.0.1.1; 6; 0; with injure; I.0.1.1.0; 0; 0; injured; I.0.1.1.0; 1; 0; injury; I.0.1.1.0; 6; 0; heal; I.0.1.1.1; 0; 0; healed; I.0.1.1.1; 1; 0; healing; I.0.1.1.1; 6; 0; healer; I.0.1.1.1; 7; 0; agonize; I.0.1.1.2; 0; 0; agonist; I.0.1.1.2; 7; 0; scavenge; I.0.1.1.3; 0; 0; scavenged; I.0.1.1.3; 1; 0; scavenger; I.0.1.1.3; 7; 0; susceptible; I.0.1.1.3; 9; 0; to impose; I.0.1.2; 0; 0; imposed; I.0.1.2; 1; 0; modulate; I.0.1.3; 0; 0; modulated; I.0.1.3; 1; 0; modulation; I.0.1.3; 6; 0; modulator; I.0.1.3; 7; 0; facilitate; I.0.1.3.0; 0; 0; facilitated; I.0.1.3.0; 1; 0; promote; I.0.1.3.0.0; 0; 0; promoted; I.0.1.3.0.0; 1; 0; promotor; I.0.1.3.0.0; 7; 0; promotion; I.0.1.3.0.0; 6; 0; initiate; I.0.1.3.0.0.0; 0; 0; initiated; I.0.1.3.0.0.0; 1; 0; initiation; I.0.1.3.0.0.0; 6; 0; initiator; I.0.1.3.0.0.0; 7; 0; trigger; I.0.1.3.0.0.0.0; 0; 0; triggered; I.0.1.3.0.0.0.0; 1; 0; trigger; I.0.1.3.0.0.0.0; 7; 0; for nucleate; I.0.1.3.0.0.0.1; 0; 0; nucleated; I.0.1.3.0.0.0.1; 1; 0; nucleation; I.0.1.3.0.0.0.1; 6; 0; nucleator; I.0.1.3.0.0.0.1; 7; 0; activate; I.0.1.3.0.0.1; 0; 0; activated; I.0.1.3.0.0.1; 1; 0; activator; I.0.1.3.0.0.1; 7; 0; activation; I.0.1.3.0.0.1; 6; 0; transactivate; I.0.1.3.0.0.1.0; 0; 0; transactivated; I.0.1.3.0.0.1.0; 1; 0; transactivator; I.0.1.3.0.0.1.0; 7; 0; transactivation; I.0.1.3.0.0.1.0; 6; 0; catalyze; I.0.1.3.0.0.2; 0; 0; catalyzed; I.0.1.3.0.0.2; 1; 0; catalysis; I.0.1.3.0.0.2; 6; 0; catalyst; I.0.1.3.0.0.2; 7; 0; enhance; I.0.1.3.0.1; 0; 0; enhanced; I.0.1.3.0.1; 1; 0; enhancement; I.0.1.3.0.1; 6; 0; enhancer; I.0.1.3.0.1; 7; 0; protect; I.0.1.3.0.1.0; 0; 0; protected; I.0.1.3.0.1.0; 1; 0; protector; I.0.1.3.0.1.0; 7; 0; protection; I.0.1.3.0.1.0; 6; 0; accelerate; I.0.1.3.0.1.1; 0; 0; accelerated; I.0.1.3.0.1.1; 1; 0; acceleration; I.0.1.3.0.1.1; 6; 0; accelerator; I.0.1.3.0.1.1; 7; 0; step; I.0.1.3.0.1.1.0;10; 0; stimulate; I.0.1.3.0.1.2; 0; 0; stimulated; I.0.1.3.0.1.2; 1; 0; stimulation; I.0.1.3.0.1.2; 6; 0; stimulator; I.0.1.3.0.1.2; 7; 0; stabilize; I.0.1.3.0.2; 0; 0; stabilized; I.0.1.3.0.2; 1; 0; stabilization; I.0.1.3.0.2; 6; 0; stabilizer; I.0.1.3.0.2; 7; 0; hamper; I.0.1.3.1; 0; 0; hampered; I.0.1.3.1; 1; 0; repress; I.0.1.3.1.0; 0; 0; repressed; I.0.1.3.1.0; 1; 0; repression; I.0.1.3.1.0; 6; 0; repressor; I.0.1.3.1.0; 7; 0; suppress; I.0.1.3.1.1; 0; 0; suppressed; I.0.1.3.1.1; 1; 0; suppression; I.0.1.3.1.1; 6; 0; supressor; I.0.1.3.1.1; 7; 0; halt; I.0.1.3.1.1.0; 0; 0; halted; I.0.1.3.1.1.0; 1; 0; stop; I.0.1.3.1.1.1; 0; 0; stopped; I.0.1.3.1.1.1; 1; 0; scatter; I.0.1.3.1.1.1.0; 0; 0; scattered; I.0.1.3.1.1.1.0; 1; 0; scattering; I.0.1.3.1.1.1.0; 6; 0; deactivate; I.0.1.3.1.1.2; 0; 0; deactivated; I.0.1.3.1.1.2; 1; 0; deactivation; I.0.1.3.1.1.2; 6; 0; deactivator; I.0.1.3.1.1.2; 7; 0; prevent; I.0.1.3.1.2; 0; 0; prevented; I.0.1.3.1.2; 1; 0; prevention; I.0.1.3.1.2; 6; 0; expose; I.0.1.3.1.2.0; 0; 0; exposed; I.0.1.3.1.2.0; 1; 0; exposure; I.0.1.3.1.2.0; 6; 0; decelerate; I.0.1.3.1.2.1; 0; 0; decelerated; I.0.1.3.1.2.1; 1; 0; deceleration; I.0.1.3.1.2.1; 6; 0; decelerator; I.0.1.3.1.2.1; 7; 0; inhibit; I.0.1.3.1.2.2; 0; 0; inhibited; I.0.1.3.1.2.2; 1; 0; inhibition; I.0.1.3.1.2.2; 6; 0; inhibitor; I.0.1.3.1.2.2; 7; 0; destabilize; I.0.1.3.1.3; 0; 0; destabilized; I.0.1.3.1.3; 1; 0; destabilization; I.0.1.3.1.3; 6; 0; destabilizer; I.0.1.3.1.3; 7; 0; neutralize; I.0.1.3.1.4; 0; 0; neutralized; I.0.1.3.1.4; 1; 0; neutralization; I.0.1.3.1.4; 6; 0; neutralizer; I.0.1.3.1.4; 7; 0; block; I.0.1.3.1.5; 0; 0; blocked; I.0.1.3.1.5; 1; 0; block; I.0.1.3.1.5; 6; 0; abolish; I.0.1.3.1.6; 0; 0; abolished; I.0.1.3.1.6; 1; 0; abolition; I.0.1.3.1.6; 6; 0; attenuate; I.0.1.3.2; 0; 0; attenuated; I.0.1.3.2; 1; 0; attenuation; I.0.1.3.2; 6; 0; attenuator; I.0.1.3.2; 7; 0; sensitize; I.0.1.3.3; 0; 0; sensitized; I.0.1.3.3; 1; 0; sensitization; I.0.1.3.3; 6; 0; sensitizer; I.0.1.3.3; 7; 0; desensitize; I.0.1.3.4; 0; 0; desensitized; I.0.1.3.4; 1; 0; desensitization; I.0.1.3.4; 6; 0; desensitizer; I.0.1.3.4; 7; 0; change; I.0.1.4; 0; 0; changed; I.0.1.4; 1; 0; change; I.0.1.4; 6; 0; of/in alter; I.0.1.4.0; 0; 0; altered; I.0.1.4.0; 1; 0; alteration; I.0.1.4.0; 6; 0; methylate; I.0.1.4.0.0; 0; 0; methylated; I.0.1.4.0.0; 1; 0; methylation; I.0.1.4.0.0; 6; 0; acetylate; I.0.1.4.0.1; 0; 0; acetylated; I.0.1.4.0.1; 1; 0; acetylation; I.0.1.4.0.1; 6; 0; de-acetylate; I.0.1.4.0.2; 0; 0; de-acetylated; I.0.1.4.0.2; 1; 0; de-acetylation; I.0.1.4.0.2; 6; 0; phosphorylate; I.0.1.4.0.3; 0; 0; phosphorylated; I.0.1.4.0.3; 1; 0; phosphorylation; I.0.1.4.0.3; 6; 0; de-phosphorylate; I.0.1.4.0.4; 0; 0; de-phosphorylated; I.0.1.4.0.4; 1; 0; dephosphorylation; I.0.1.4.0.4; 6; 0; hydrolyse; I.0.1.4.0.5; 0; 0; hydrolysed; I.0.1.4.0.5; 1; 0; hydrolysis; I.0.1.4.0.5; 6; 0; augment; I.0.1.4.1; 0; 0; augmented; I.0.1.4.1; 1; 0; augmentation; I.0.1.4.1; 6; 0; of/in increase; I.0.1.4.1.0; 0; 0; increased; I.0.1.4.1.0; 1; 0; increase; I.0.1.4.1.0; 6; 0; of/in enlarge; I.0.1.4.1.1; 0; 0; enlarged; I.0.1.4.1.1; 1; 0; enlargement; I.0.1.4.1.1; 6; 0; reduce; I.0.1.4.2; 0; 0; reduced; I.0.1.4.2; 1; 0; reduction; I.0.1.4.2; 6; 0; of/in decrease; I.0.1.4.2.0; 0; 0; decreased; I.0.1.4.2.0; 1; 0; decrease; I.0.1.4.2.0; 6; 0; of/in # COMMENT: 'part-of-a-whole/mechanism' influence contribute; I.0.2; 0; 0; to contribution; I.0.2; 6; 0; to contributor; I.0.2; 7; 0; to specify; I.0.2.0; 0; 0; specified; I.0.2.0; 1; 0; specification; I.0.2.0; 6; 0; specifier; I.0.2.0; 7; 0; code; I.0.2.0.0; 0; 0; coded; I.0.2.0.0; 1; 0; encode; I.0.2.0.1; 0; 0; encoded; I.0.2.0.1; 1; 0; encoding; I.0.2.0.1; 6; 0; encoder; I.0.2.0.1; 7; 0; control; I.0.2.1; 0; 0; controlled; I.0.2.1; 1; 0; control; I.0.2.1; 6; 0; controller; I.0.2.1; 7; 0; regulate; I.0.2.1.0; 0; 0; regulated; I.0.2.1.0; 1; 0; regulation; I.0.2.1.0; 6; 0; regulator; I.0.2.1.0; 7; 0; up-regulate; I.0.2.1.0.0; 0; 0; up-regulated; I.0.2.1.0.0; 1; 0; up-regulation; I.0.2.1.0.0; 6; 0; up-regulator; I.0.2.1.0.0; 7; 0; deregulate; I.0.2.1.1; 0; 0; deregulated; I.0.2.1.1; 1; 0; deregulation; I.0.2.1.1; 6; 0; deregulator; I.0.2.1.1; 7; 0; down-regulate; I.0.2.1.1.0; 0; 0; down-regulated; I.0.2.1.1.0; 1; 0; down-regulation; I.0.2.1.1.0; 6; 0; down-regulator; I.0.2.1.1.0; 7; 0; mediate; I.0.2.1.2; 0; 0; mediated; I.0.2.1.2; 1; 0; mediation; I.0.2.1.2; 6; 0; mediator; I.0.2.1.2; 7; 0; abrogate; I.0.2.1.3; 0; 0; abrogated; I.0.2.1.3; 1; 0; abrogation; I.0.2.1.3; 6; 0; cause; I.0.2.2; 0; 0; caused; I.0.2.2; 1; 0; cause; I.0.2.2; 6; 0; due; I.0.2.2.0; 9; 0; to lead; I.0.2.2.1; 0; 0; to result; I.0.2.2.1.0; 0; 0; in result; I.0.2.2.1.0; 6; 0; result; I.0.2.2.1.0; 10; 0; from effect; I.0.2.2.1.1; 6; 0; on follow; I.0.2.2.2; 10; 0; from consequence; I.0.2.2.2.0; 10; 0; of involve; I.0.2.3; 2; 0; involved; I.0.2.3; 8; 0; in involvement; I.0.2.3; 6; 0; in comprise; I.0.2.3.0; 2; 0; comprised; I.0.2.3.0; 3; 0; utilize; I.0.2.3.1; 2; 0; utilized; I.0.2.3.1; 3; 0; utilization; I.0.2.3.1; 6; 0; depend; I.0.2.3.1.0; 2; 0; on dependent; I.0.2.3.1.0; 9; 0; on dependence; I.0.2.3.1.0; 6; 0; ; on independent; I.0.2.3.1.1; 9; 1; of independence; I.0.2.3.1.1; 6; 1; ; from participate; I.0.2.3.2; 0; 0; in participation; I.0.2.3.2; 6; 0; in participant; I.0.2.3.2; 7; 0; in role; I.0.2.3.2.0; 6; 0; in function; I.0.2.3.2.0.1; 0; 0; in responsible; I.0.2.3.2.0.2; 8; 0; for determine; I.0.2.3.2.0.3; 0; 0; determined; I.0.2.3.2.0.3; 1; 0; determination; I.0.2.3.2.0.3; 6; 0; determinant; I.0.2.3.2.0.3; 7; 0; of/for/in implicate; I.0.2.3.2.1; 4; 0; in implicated; I.0.2.3.2.1; 5; 0; in require; I.0.2.3.2.1.0; 2; 0; required; I.0.2.3.2.1.0; 3; 0; by/for requirement; I.0.2.3.2.1.0; 6; 0; for suffice; I.0.2.3.2.1.1; 0; 0; for sufficient; I.0.2.3.2.1.1; 8; 0; for critical; I.0.2.3.2.1.2; 8; 0; for intermediate; I.0.2.3.2.1.3; 7; 0; in/of factor; I.0.2.3.2.1.4; 7; 0; in step; I.0.2.3.2; 10; 0; limit; I.0.2.3.2.0; 0; 0; limited; I.0.2.3.2.0; 1; 0; agent; I.0.2.4; 7; 0; in/of/for # COMMENT:influence with a time aspect proceed; I.0.3; 0; 0; achieve; I.0.3.0; 0; 0; achieved; I.0.3.0; 1; 0; achievement; I.0.3.0; 6; 0; achiever; I.0.3.0; 7; 0; respond; I.0.3.1; 0; 0; to response; I.0.3.1; 6; 0; to responder; I.0.3.1; 7; 0; to non-response; I.0.3.1; 6; 1; to non-responder; I.0.3.1; 7; 1; to signal; I.0.3.2; 0; 0; signalled; I.0.3.2; 1; 0; signalling; I.0.3.2; 6; 0; transduce; I.0.3.2.0; 0; 0; transduced; I.0.3.2.0; 1; 0; transduction; I.0.3.2.0; 6; 0; transducer; I.0.3.2.0; 7; 0; isolate; I.0.3.2.1; 0; 0; isolated; I.0.3.2.1; 1; 0; isolation; I.0.3.2.1; 6; 0; characterize; I.0.3.2.2; 0; 0; characterized; I.0.3.2.2; 1; 0; characterization; I.0.3.2.2; 6; 0; predict; I.0.3.2.3; 0; 0; predicted; I.0.3.2.3; 1; 0; prediction; I.0.3.2.3; 6; 0; display; I.0.3.2.4; 0; 0; displayed; I.0.3.2.4; 1; 0; display; I.0.3.2.4; 6; 0; exhibit; I.0.3.2.4.0; 0; 0; exhibited; I.0.3.2.4.0; 1; 0; exhibition; I.0.3.2.4.0; 6; 0; exhibitor; I.0.3.2.4.0; 7; 0; generate; I.0.3.3; 0; 0; generated; I.0.3.3; 1; 0; generation; I.0.3.3; 6; 0; generator; I.0.3.3; 7; 0; metabolize; I.0.3.3.0; 0; 0; metabolized; I.0.3.3.0; 1; 0; metabolization; I.0.3.3.0; 6; 0; metabolism; I.0.3.3.0; 10; 0; anabolize; I.0.3.3.0.0; 0; 0; anabolized; I.0.3.3.0.0; 1; 0; anabolization; I.0.3.3.0.0; 6; 0; anabolism; I.0.3.3.0.0; 6; 0; catabolize; I.0.3.3.0.1; 0; 0; catabolized; I.0.3.3.0.1; 1; 0; catabolization; I.0.3.3.0.1; 6; 0; catabolism; I.0.3.3.0.1; 6; 0; develop; I.0.3.3.1; 0; 0; developed; I.0.3.3.1; 1; 0; development; I.0.3.3.1; 6; 0; induce; I.0.3.3.2; 0; 0; induced; I.0.3.3.2; 1; 0; induction; I.0.3.3.2; 6; 0; inductor; I.0.3.3.2; 7; 0; autoinduce; I.0.3.3.2.0; 0; 0; autoinduced; I.0.3.3.2.0; 1; 0; autoinduction; I.0.3.3.2.0; 6; 0; autoinductor; I.0.3.3.2.0; 7; 0; produce; I.0.3.3.3; 0; 0; produced; I.0.3.3.3; 1; 0; production; I.0.3.3.3; 6; 0; producer; I.0.3.3.3; 7; 0; secrete; I.0.3.3.3.0; 0; 0; secreted; I.0.3.3.3.0; 1; 0; secretion; I.0.3.3.3.0; 6; 0; secretor; I.0.3.3.3.0; 7; 0; isolate; I.0.3.3.3.1; 0; 0; isolated; I.0.3.3.3.1; 1; 0; isolation; I.0.3.3.3.1; 6; 0; form; I.0.3.3.3.2; 0; 0; formed; I.0.3.3.3.2; 1; 0; formation; I.0.3.3.3.2; 6; 0; reverse; I.0.3.4; 0; 0; reversed; I.0.3.4; 1; 0; reversal; I.0.3.4; 6; 0; degrade; I.0.3.5; 0; 0; degraded; I.0.3.5; 1; 0; degradation; I.0.3.5; 6; 0; degrader; I.0.3.5; 7; 0; #splice/splicing (alternative) #based on